The GLP-1 Drugs

In recent years, the topic of the GLP-1s, drugs such as Ozempic, Wegovy, Mounjaro, Zepound and others has taken the forefront of the discussion of the treatment of overweight and obesity.  And understandably so, given that they represent the first true improvement on the issue.    For a field that has, for decades, failed to achieve its goals of helping people to lose weight and fat and, more importantly, to keep it off, the GLP-1s have truly changed the game.

But while many articles hold the GLP-1s as magical compounds, others decry them for various reasons (which all fundamentally come down to rationalizing moralistic beliefs about overweight and obesity).  Side effects are continually overemphasized and reported in such a way as to make the GLP-1s sound much worse than they are.  People are confused, bewildered, misled and scared in equal amounts.  Someone needed to set the record straight and I figured it might as well be me.  … Keep Reading

So last Wednesday I put up my analysis of the new Barbalho et. al paper on training volume in men, basically an identical study to the one they did on women.   Given it’s methodological superiority, I once again compared it to Brad’s paper.

As expected Brad and James made typical guru-deflections over my comments.  Because dismissing criticism out of hand is always easier than addressing it honestly or examining your own limitations or trying to actually fix them.

So to them I issue the following challenges:

If the embedding doesn’t work, click this link.

So there ya’ go guys.  My challenges to you.  Specific instructions on how you can easily, oh so easily, shut me the fuck up.    It’s what you all want to do, right?  So now you have the chance to do it.

In the roughly 25 years I’ve been doing this and issued such challenges, exactly one person stepped up and he got taken out of the gym in an ambulance. … Keep Reading

So on Thursday December 14th what I am calling the Brawl to Settle Absofuckinglutely Nothing occurred between myself and Mike Israetel.  I guess this means that Mike and I were each other’s Valentine’s day date.  Take that how you will.

Since the discussion was time limited (it still went 90 minutes), there were some things in the middle that weren’t addressed.  More than that, it would have just lengthened it to go in circles.  So I’m using this platform to talk about them.  Mike can do the same.

First, one very important comment, in much of this I have been spelling Mike’s last name wrong, as Isratel.  It wasn’t deliberate, just a mistake.  It’s Israetel and I will make efforts in the future to get it right.  I certainly meant to mention this in the debate and hope I did.  Already the memories fade.  But I wanted to make that correction.… Keep Reading