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Bodyweight Regulation: Leptin and More

For decades there has been a lot of debate over the idea that bodyweight is regulated.   Decades of research suggests that there is a biological setpoint although others feel that a bodyweight settling point is a more accurate description of the system.  Likely both play a role.

An additional question is whether it is bodyweight or body fat that is being regulated.  Likely both play some sort of a role.  However, inasmuch as body fat levels tend to be the most impacted by a diet, it makes sense that a primary signal to the brain of what was going on would reside in the body fat.  The question then became what it was or even might be.

It would be decades later that the answer, or at least a partial answer would become apparent.  That answer was leptin.

The Eventual Discovery of Leptin

With early research (I’m talking the 1950’s) having established the existence of some type of setpoint (again, primarily in animal models), early researchers had to sort of guess what might be going on in terms of regulating body fat levels.… Keep Reading

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Set points, Settling points and Bodyweight Regulation

Having explained why the separation of psychology and physiology is a false separation in Dieting Psychology vs. Dieting Physiology, I want to discuss quickly some of the physiology behind diet failures. This is a topic that I discuss in detail in nearly all of my recent books and I’m not going to spend endless time on it here (trying to eventually get back to the psychological factors behind diet failures).

A long standing debate in the world of obesity research revolves around the idea that bodyweight (or perhaps body fat) is regulated. What does that mean exactly?

Bodyweight Regulation

Think about your thermostat (yes, this is the example I always use): you set it to keep the house at 80 degrees and it continually senses the temperature (via a thermometer). If the temperature goes above 80 degrees, the air conditioning comes on; if it drops below 80, the heat comes on.… Keep Reading

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A Guide to Fat Loss for Athletes

Losing body fat is often an issue for athletes and there are various and sundry (yes, sundry) reasons that they either want or need to do this. Clearly for the physique sports (bodybuilding, fitness, figure), it’s an issue of appearance. For performance sports (everything else), losing fat or weight can often improve performance. Either the athlete can get into a lower weight class (if their sport has such) or they can improve their strength or power to weight ratio, improving performance.

I’d note, and this would be a topic for an entirely separate article, that leaner is not always better. Most sports end up having an ideal level of leanness where higher and lower levels aren’t consistent with optimal performance. Many athletes will over train or lose muscle mass and performance in the quest to get as lean as possible and this often does more harm than good.

Unfortunately, athletes often approach the goal of fat loss in an absolutely awful way.… Keep Reading

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What is Body Fat?

Note: The following is the entirety of Chapter 2 from my Stubborn Fat Solution where I describe what human body fat actually is.

Most people think they know all there is to know about body fat; I’m here to tell you that that isn’t the case.  If you’ve read my articles, you may have seen some of this before but I want to make sure everyone is on the same page before I deluge you with the technical bits.

What is Bodyfat?

The more technical term for body fat is adipose tissue, with individual cells being called adipocytes (adipo = fat ; cyte = cell). In humans, the primary type of fat cell is called white adipose tissue, or WAT, so named because of its color (it’s actually sort of a milky yellow). While there is another type of fat, called brown adipose tissue or BAT (which is actually reddish/orangeish), it’s generally been thought that humans didn’t have much BAT and hence it could be ignored. … Keep Reading

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Homeostatic and Non-Homeostatic Pathways and Food Intake

I don’t know how much the readers of my site care about the depths of neurobiology, although I wouldn’t be surprised if I had some given how I write or what I write about.  In any case, this is somewhat technical article where I want to look at what are called the homeostatic and non-homeostatic (or hedonic) pathways and how they impact on food intake.

The very simple distinction between the two is that the homeostatic system is involved in regulating food intake based on the body’s actual needs whereas the non-homeostatic/hedonic system is based on environmental factors and the fact that food tastes good.  Now let’s look at the complex distinction.  First let me start with a couple of definitions.

Regulation

The idea of regulation means that, well, a system is regulated.  Ok, that doesn’t help.  What this means is that a system has some way of attempting to keep itself at a fairly consistent level.   … Keep Reading